mitochondrial oxidative phosphorylation disorder severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency https://github.com/monarch-initiative/mondo/issues/7568 GARD:0028027 Orphanet:397593 Rare, hereditary, mitochondrial oxidative phosphorylation disorder characterized by severe neonatal lactic acidosis and deficiency of mitochondrial complexes I, II and III. Clinical features are variable and may include hypotonia, respiratory distress with cyanosis, failure to thrive, feeding difficulties, hypoglycemia, dehydration, vomiting, seizures, and a risk of multiple organ failure. MONDO:0700371 UMLS:C4750855 MEDGEN:1658790