temporal lobe epilepsy variable-age onset focal epilepsy syndrome familial mesial temporal lobe epilepsy https://github.com/monarch-initiative/mondo/issues/7693 https://github.com/monarch-initiative/mondo/issues/8455 A focal epilepsy syndrome where the age at onset is typically in adolescence or adulthood. Affected individuals have focal aware seizures with mesial temporal lobe features, especially prominent déjà vu. Most patients have a normal MRI, and seizures respond to treatment. A subgroup is recognised that have antecedent febrile seizures, hippocampal atrophy, and drug resistant seizures. Direct questioning of relatives may be required to identify this familial epilepsy syndrome, as many individuals consider their déjà vu experiences as mild and they may not have been diagnosed as seizures. Orphanet:163717 MONDO:0800493 GARD:0027392 According to ILAE, there is complex/polygenic inheritance, with rare families reported with Mendelian inheritance, which may be recessive or dominant. (https://www.epilepsydiagnosis.org/syndrome/other-familial-temporal-lobe-genetics.html) FMTLE