has material basis in germline mutation in MBD4 hereditary neoplastic syndrome tumor predisposition syndrome 2 https://github.com/monarch-initiative/mondo/issues/8214 https://www.malacards.org/card/tumor_predisposition_syndrome_2 MBD4-related recessive tumor predisposition syndrome UMLS:C5774186 MBD4-associated neoplasia syndrome Orphanet:661526 MANS OMIM:619975 TPDS2 MONDO:0859267 An autosomal recessive cancer predisposition syndrome characterized by the onset of various types of tumors or malignancies in young adulthood. The most common clinical manifestations include acute myeloid leukemia (AML), myelodysplastic syndrome, colorectal adenomatous polyposis and carcinoma, and uveal melanoma. MEDGEN:1823959 GARD:0026684