leukodystrophy adult-onset progressive leukoencephalopathy-early-onset deafness https://www.malacards.org/card/adult_onset_progressive_leukoencephalopathy_early_onset_deafness MONDO:0958094 Orphanet:652532 GARD:0026925 MEDGEN:1859137 UMLS:C5921954 A rare genetic neurological disorder characterized by congenital or early-onset sensorineural deafness and adult-onset progressive leukoencephalopathy. Progressive cognitive impairment and behavioral abnormalities are observed in the second or third decade of life, sometimes preceded by mild developmental delay and learning difficulties. Visual impairment in adult age has been reported. No central nervous system calcification is reported.