has material basis in germline mutation in SCN5A cardiogenetic rhythm disorder SCN5A-related cardiac rhythm disorder https://github.com/monarch-initiative/mondo/issues/9707 MONDO:1010181 Individuals with pathogenic variants in SCN5A may also exhibit overlapping or mixed cardiac rhythm phenotypes and intrafamilial variability. SCN5A-related cardiac rhythm disorder A heterogeneous collection of cardiac rhythm disorders caused by genetic variations in the SCN5A gene with autosomal dominant inheritance. Affected individuals are commonly reported to have unremarkable cardiac morphology and at least one cardiac rhythm phenotype that includes, but is not limited to, atrial fibrillation, sick sinus syndrome, progressive cardiac conduction disease, ventricular fibrillation, long QT syndrome, and Brugada syndrome.