has material basis in germline mutation in PRPF19 Mendelian neurodevelopmental disorder PRPF19-related neurodevelopmental disorder https://github.com/monarch-initiative/mondo/issues/8489 https://github.com/monarch-initiative/mondo/issues/8156 MONDO:1040005 Any neurodevelopmental disorder in which the cause of the disease is a mutation in the PRPF19 gene. This disorder is characterised by developmental, motor and speech delay, and facial dysmorphisms. Most patients present mild to moderate intellectual disability, autism spectrum disorder or autistic features, and hypotonia. Other phenotypes observed less frequently include seizures, and visual and cardiac abnormalities.