has material basis in germline mutation in EDA ectodermal dysplasia syndrome EDA-related ectodermal dysplasia MONDO:1060241 Any ectodermal dysplasia syndrome in which the cause of the disease is a variation in the EDA gene. Key features are hypohidrosis and hypotrichosis; the condition is also characterized by skin anomalies such as soft, thin, and dry skin, eczema, and pigmentation anomalies, as well as fine or brittle hair, dental anomalies such as hypodontia or oligodontia, vocal hoarseness, and hyperthermia susceptibility. https://github.com/monarch-initiative/mondo/issues/10189 EDA-related ectodermal dysplasia