has material basis in germline mutation in predisposes towards TMEFF1 herpes simplex encephalitis encephalitis, acute, infection-induced, susceptibility to herpes simplex encephalitis due to TMEFF1 deficiency https://github.com/monarch-initiative/mondo/issues/10644 herpes simplex encephalitis, susceptibility to, TMEFF1-related TMEFF1 deficiency An inherited susceptibility to acute infection-induced encephalitis in which the cause is a variation in the TMEFF1 gene, predisposing to herpes simplex encephalitis. Genetic TMEFF1 deficiency allows HSV-1 to rapidly enter cortical neurons. MONDO:1060314