disease arises from feature disease has basis in feature diabetes mellitus cystic fibrosis cystic fibrosis-related diabetes CFRD CF-related diabetes ICD10CM:E13 MONDO:7770003 A form of diabetes mellitus unique to individuals with cystic fibrosis (CF), arising primarily from progressive fibrotic destruction of the pancreas leading to insulin deficiency, with additional contributions from insulin resistance. CFRD affects approximately 20% of adolescents and 40-50% of adults with CF. It shares features with both type 1 and type 2 diabetes but is a distinct clinical entity with its own diagnostic criteria and management guidelines.