has role has role polypeptide peptide hormone antineoplastic agent appetite enhancer antiatherogenic agent apoptosis inducer ghrelin Motilin-related peptide GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR Human ghrelin Ghrelin (human) Gastric MLTRP A 28-membered appetite-stimulating polypeptide consisting of Gly, Ser, Ser(octanoyl), Phe, Leu, Ser, Pro, Glu, His, Gln, Arg, Val, Gln, Gln, Arg, Lys, Glu, Ser, Lys, Lys, Pro, Pro, Ala, Lys, Leu, Gln, Pro and Arg residues joined in sequence. The <em>O</em>-<em>n</em>-octanoylation of the side-chain hydroxy group of serine-3 (Ser3) is essential for ghrelin's activity. H-Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH GSS(octanoyl)FLSPEHQRVQQRKESKKPPAKLQPR CHEBI:75431 chebi_ontology Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg human metabolite