lacks_part participates in participates in pre-B-II cell large pre-B-II cell Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. large pre-BII cell large pre-B cell A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative. lymphocyte proliferation V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2