part of part of intestinal crypt stem cell epithelial cell of large intestine intestinal crypt stem cell of large intestine crypt stem cell of large intestine An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells. stem cell of large intestine crypt of Lieberkuhn crypt of Lieberkuhn of large intestine