GABAergic neuron medium spiny neuron BTO:0004778 medium-sized densely spiny neuron striatal medium spiny neuron An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus. gamma-aminobutyric acid ergic spiny projection neuron Direct genetic lineage tracing in mice, including Dlx-based and Sp9-Cre fate mapping, demonstrates that medium spiny neurons (MSNs) originate from progenitors in the lateral ganglionic eminence (LGE), with labeled cells migrating from LGE to the striatum and expressing MSN markers such as FOXP1 and CTIP2. gamma-aminobutyric acid (GABA)ergic spiny projection neuron lateral ganglionic eminence derived neuron