negatively regulates negatively regulates cell cycle checkpoint signaling https://github.com/geneontology/go-ontology/issues/20935 This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here. cell cycle checkpoint biological_process GO:0031576 signal transduction involved in cell cycle checkpoint G2/M checkpoint A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. Reactome:R-HSA-69620 G1/S checkpoint GO:0072395 signal transduction involved in G2/M transition checkpoint Wikipedia:Cell_cycle_checkpoint G1/S transition checkpoint GO:0000075 GO:0072407 GO:0071779 GO:0072404 G2/M transition checkpoint intracellular signal transduction cell cycle phase transition negative regulation of cell cycle phase transition