part of part of tricarboxylic acid cycle https://github.com/geneontology/go-ontology/issues/28429 https://github.com/geneontology/go-ontology/issues/28527 GO:0006099 A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. Wikipedia:Tricarboxylic_acid_cycle MetaCyc:TCA Krebs cycle MetaCyc:PWY66-398 Reactome:R-HSA-71403 biological_process oxidative TCA cycle citric acid cycle MetaCyc:TCA-1 MetaCyc:PWY-5913 MetaCyc:P105-PWY MetaCyc:PWY-6969 MetaCyc:PWY-5690 MetaCyc:PWY-7254 TCA cycle MetaCyc:REDCITCYC aerobic respiration primary metabolic process