sex-chromosome dosage compensation dosage compensation by inactivation of X chromosome https://github.com/geneontology/go-ontology/issues/25955 Wikipedia:X-inactivation biological_process GO:0009048 chromosome inactivation Barr body formation X chromosome inactivation Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. heterochromatin formation