O-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity catechol O-methyltransferase activity https://github.com/geneontology/go-ontology/issues/30193 RHEA:17877 S-adenosyl-L-methionine:catechol O-methyltransferase activity RHEA:72243 RHEA:72247 molecular_function RHEA:51268 catecholamine O-methyltransferase activity catechol methyltransferase activity MB-COMT (membrane-bound form of catechol-O-methyltransferase) COMT II Reactome:R-HSA-175983 EC:2.1.1.6 COMT I GO:0016206 RHEA:73719 RHEA:72255 Catalysis of the reaction: a catechol + S-adenosyl-L-methionine = a guaiacol + H+ + S-adenosyl-L-homocysteine. Acts on catechols and on catecholamines such as adrenaline or noradrenaline. RHEA:72259 S-COMT (soluble form of catechol-O-methyltransferase) MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN Reactome:R-HSA-8955010 RHEA:72251