negatively regulates negatively regulates chromatin binding negative regulation of chromatin binding 2010-05-19T10:29:06Z Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. bf GO:0035562 negative regulation of binding biological regulation