part of part of alpha-beta T cell activation involved in immune response T cell differentiation involved in immune response T-helper 1 type immune response T-helper cell differentiation T-helper 1 cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. T-helper 1 cell development GO:0045063