necroptotic process activation of necroptosis of activated-T cells induction of necroptosis by extracellular signals extracellular signal-induced necroptosis PARP-dependent cell death induction of necroptosis of activated-T cells establishment of necroptosis parthanatos Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097. TNF-induced necroptosis Reactome:R-HSA-5213460 activation of necroptosis in response to extracellular signals RIPK1-mediated regulated necrosis establishment of necroptosis of activated-T cells A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. GO:0070266 activation of necroptosis programmed necrotic cell death necroptosis induction of necroptosis GO:0060553 GO:0060554 GO:0060555 activation of necroptosis by extracellular signals programmed necrosis biological_process programmed necrotic cell death