programmed cell death programmed necrotic cell death 2012-05-04T03:03:39Z regulated necrosis biological_process GO:0097300 Reactome:R-HSA-5218859 programmed cell death by necrosis A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. pr This term may be used when annotating instances of programmed cell death characterized by necrotic morphology where the involvement of RIPK1 and/or RIPK3 is not shown. See PMID:23818611 for some examples.