ATPase-coupled transmembrane transporter activity P-type transmembrane transporter activity https://github.com/geneontology/go-ontology/issues/20529 https://github.com/geneontology/go-ontology/issues/21273 GO:0140358 P-type ATPase pg 2019-06-25T19:07:46Z Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. Wikipedia:P-type_ATPase molecular_function E1-E2 ATPase TC:3.A.3