obsolete abnormal tumor necrosis factor physiology true OBSOLETE. functional anomaly of this cytokine produced by macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium MP:0008752 abnormal TNFA physiology MP:0008556 abnormal TNF physiology abnormal tumor necrosis factor alpha physiology This term is obsolete. Instead, use the terms abnormal tumor necrosis factor level (MP:0008752) and its children or abnormal tumor necrosis factor secretion (MP:0008556) and its children. abnormal cachectin physiology MPheno.ontology MP:0002530