increased susceptibility to infection increased susceptibility to prion infection decreased resistance to prion infection MP:0005364 increased likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component MP:0003004 MPheno.ontology susceptibility to prion infection abnormal susceptibility to prion infection