has part has part has_part characteristic of has modifier pancreatic centro-acinar cell abnormal pancreatic acinus morphology abnormal centroacinar cell of Langerhans morphology abnormal centro-acinar cell of Langerhans morphology MPheno.ontology 2010-06-01T02:40:50Z abnormal pancreatic centro-acinar cell morphology abnormal pancreatic centroacinar cell morphology csmith MP:0010171 any structural anomaly of the cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the pancreatic acinus; this cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types Centroacinar cells liet at the junction between the acinus and the ductal cells of the intercalated duct, are smaller than acinar cells, have a high nuclear-to-cytoplasm ratio, and have long cytoplasmic processes that allow contact with other cells (i.e., centroacinar, acinar, and islet cells). Some authors suggest that centroacinar cells could represent progenitor multipotent pancreatic cells and potentially be involved in malignant transformation morphology abnormal pancreatic acinus