has part has part has_part characteristic of has modifier kidney collecting duct principal cell abnormal kidney collecting duct principal cell morphology MP:0011757 csmith 2012-10-29T02:32:19Z any structural abnormality of the cuboidal epithelial cells found in the collecting ducts of the kidney which regulate sodium and potassium balance via channels located on the cells apical membrane. Aldosterone increases the number of Na+/K+-ATPase pumps that allow increased sodium reabsorption and potassium secretion whereas antidiuretic hormone (vasopressin) determines the expression of aquaporin channels on the cell surface; together, aldosterone and vasopressin let the principal cell control the quantity of water that is reabsorbed MPheno.ontology abnormal kidney collecting duct epithelium morphology morphology abnormal