impaired neural crest cell differentiation abnormal cardiac neural crest cell morphology impaired cardiac neural crest cell differentiation abnormal or arrest of differentiation or patterning of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs have the potential to differentiate into smooth muscle cells of the cardiac outflow tract and its septum, walls of aortic and arch-derived arteries, all of the parasympathetic innervation of the heart, and the connective tissue of the glands in the head and neck region, including the thymus, thyroid and parathyroid glands MPheno.ontology 2014-03-27T16:26:22Z MP:0012751 impaired cardiac NCC differentiation csmith