abnormal skeletal muscle morphology rhabdomyolysis 2020-07-07T10:04:24Z breakdown of skeletal muscle fibers leading to leakage of muscle contents into the bloodstream; damage to the sarcolemma results in loss of its intrinsic function, an influx of calcium, activation of intracellular proteases, and release of intracellular contents (e.g. myoglobin, creatine phosphokinase, aldolase, lactate dehydrogenase, aspartate transaminase, and potassium) into the circulation; common causes include trauma, prolonged exertion, hyperthermia, infections, electrolyte abnormalities, electrical current injury, drugs or toxins, and conditions that cause tissue hypoxia; complications may include acute renal failure, metabolic abnormalities, and disseminated intravascular congestion MPheno.ontology MP:0031112