abnormal ovulation cycle abnormal luteolysis 2022-06-20T12:43:29Z The regression of the corpus luteum is essential to reset the ovarian cycle, so that mammals obtain another chance to become pregnant. abnormal corpus luteum regression abnormal CL regression abnormal luteal regression MPheno.ontology MP:0031423 any anomaly in the structural and functional degradation of the corpus luteum occurring at the end of the luteal phase of both the estrous and menstrual cycles in the absence of pregnancy; during normal luteolysis, loss of the capacity to synthesize and secrete progesterone (functional luteolysis) is followed by loss of the cells that comprise the corpus luteum (structural luteolysis)