has part has part has_part characteristic of has modifier smooth endoplasmic reticulum abnormal endoplasmic reticulum morphology abnormal smooth endoplasmic reticulum morphology 2025-10-06T11:23:38Z abnormal smooth ER morphology abnormal SER morphology MP:0031686 The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. any structural anomaly of the form of the endoplasmic reticulum that has no ribosomes attached to its outer surface, giving it a smooth appearance MPheno.ontology morphology abnormal