has part has part has_part characteristic of has modifier type I interferon production abnormal interferon secretion abnormal interferon type I secretion 2026-02-18T09:47:11Z abnormal type I interferon secretion Together with IFN-beta, type I IFNs comprise multiple IFN-alpha subtypes (11 in mice and 13 in humans), IFN-epsilon, IFN-kappa, and IFN-omega in most mammals. In addition, IFN-delta, IFN-zeta (limitin), and IFN-tau have been detected exclusively in pigs, mice, and ruminants, respectively. In addition to being induced in response to viruses, they are also produced in immune responses to other classes of pathogens covering bacteria, parasites, and fungi. anomaly in the production or release of any of the cytokines that bind to the IFN-alpha receptor (IFNAR) complex, a heterodimer of IFNAR1 and IFNAR2 chains, and fulfill key functions in anti-viral immunity MPheno.ontology MP:0031703 abnormal IFN type I secretion abnormal type I IFN secretion abnormal process quality