abnormal podosome assembly 2026-04-20T13:12:42Z MP:0031723 abnormal podosome formation MPheno.ontology Podosomes, actin-rich protrusions on the cell membrane, act as adhesion sites between the actin skeleton and the extracellular matrix, constantly assembling and disassembling. The specific microenvironment shapes the dynamic behavior of these structures, with actin-myosin contractility and microtubules acting as key regulators of their assembly and turnover. any anomaly in the aggregation, arrangement and/or bonding together of a set of components to form a podosome abnormal podosome physiology