hypertrophic tissue hepatocytomegaly Hepatocellular hypertrophy. Hepatocytomegaly is an enlargement of the hepatocytes and is generally classified into three types: hepatocellular hypertrophy, megalocytosis, and hepatocellular vacuolation. Hepatocellular hypertrophy is an enlargement of cellular diameter without accompanying nuclear changes, leading to a net gain in the dry mass of the liver. Megalocytosis is characterized by enlargement of both the cell and the nucleus, and hepatocellular vacuolation is characterized by vacuolation, or formation of pockets of fluid within the hepatocytes. Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume. MPATH:632 PMID:7943185 mouse_pathology.ontology