cefatrizine (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (7R)-7-(alpha-D-4-hydroxyphenylglycylamino)-3-(1H-1,2,3-triazol-4-ylthiomethyl)-3-cephem-4-carboxylic acid 462.078 462.506 A cephalosporin compound having (1H-1,2,3-triazol-4-ylsulfanyl)methyl and [(2R)-2-amino-2-(4-hydroxyphenyl)]acetamido side-groups. An antibacterial drug first prepared in the 1970s, it has more recently been found to be an inhibitor of eukaryotic elongation factor-2 kinase (eEF2K), which is known to regulate apoptosis, autophagy and ER stress in many types of human cancers. BL-S 640 BL-S640 BLS 640 C18H18N6O5S2 CAS:51627-14-6 CHEBI:131730 Drug_Central:529 InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1 KEGG:D02406 N=1NC=C(N1)SCC2=C(N3[C@](SC2)([C@@](C3=O)(NC([C@H](N)C=4C=CC(=CC4)O)=O)[H])[H])C(=O)O PMID:1137381 PMID:2329468 PMID:23894823 PMID:239917 PMID:26776155 PMID:3915469 PMID:6660858 PMID:813573 Patent:DE2316866 Patent:DE2364192 Patent:US3867380 Reaxys:8172545 SKF 60771 UOCJDOLVGGIYIQ-PBFPGSCMSA-N Wikipedia:Cefatrizine antibiotic BL-S 640 cefatrizina cefatrizine cefatrizinum chebi_ontology amino acid amide cephalosporin carboxylic acid phenols triazoles semisynthetic derivative