has role aphidicolin (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol (3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol 338.246 338.482 A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. Aphidicolin Beilstein:4689958 C20H34O4 CAS:38966-21-1 CHEBI:2766 InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 KEGG:C06088 KNApSAcK:C00000873 KNApSAcK:C00023944 MetaCyc:CPD-11426 NOFOAYPPHIUXJR-APNQCZIXSA-N PMID:10592317 PMID:1483268 PMID:19735659 PMID:21212237 PMID:21444690 PMID:21708134 PMID:21812410 PMID:21897020 PMID:21917855 PMID:22139884 PMID:22210918 PMID:22262459 PMID:22293751 PMID:22302683 PMID:22339690 PMID:22365495 PMID:24492257 PMID:25948499 PMID:26255574 PMID:26854444 PMID:7478586 Patent:US3761512 Reaxys:2055641 Wikipedia:Aphidicolin [C@]12([C@]([C@@]([C@@H](CC1)O)(CO)C)(CC[C@@]3([C@@]24CC[C@]([C@H](C3)C4)(O)CO)[H])[H])C aphidocolin chebi_ontology antimicrobial agent tetracyclic diterpenoid