polypeptide peptide antibiotic lantibiotic A class of peptide antibiotic characterised by the presence of the rare thioether amino acids lanthionine or methyllanthionine, as well as the unsaturated amino acids dehydroalanine and 2-aminoisobutyric acid. In contrast to classical peptide antibiotics, lantibiotics are synthesised from precursor genes using the ribosomal pathway and the characteristic rare amino acids are introduced by posttranslational modification procedues into the lantibiotic precursor peptides ('prepeptides'). Lantibiotics are subdivided into two types: type A have long, flexible structures, while type B have rigid, globular structures. CHEBI:71644 PMID:10584332 PMID:10826980 PMID:10931442 PMID:11348686 PMID:12369187 PMID:15700960 PMID:16917798 PMID:17506681 PMID:18220976 PMID:19149587 PMID:19275538 PMID:19393544 PMID:21464591 PMID:21960309 PMID:22329892 PMID:8264800 PMID:8688628 PMID:8775975 PMID:9891793 Wikipedia:Lantibiotics chebi_ontology lantibiotics