dicarboxylic acid amide N-acylpiperazine N-alkylpiperazine indolecarboxamide chloroindole aromatic amide aromatic ketone monofluorobenzenes talmapimod 2-(6-chloro-5-{(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine-1-carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide 512.199 513.004 An indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties. C27H30ClFN4O3 CAS:309913-83-5 CHEBI:90683 CN(C)C(C(=O)C=1C=2C=C(C(=CC2N(C1)C)Cl)C(=O)N3[C@H](C)CN([C@H](C3)C)CC4=CC=C(F)C=C4)=O InChI=1S/C27H30ClFN4O3/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28/h6-11,15-17H,12-14H2,1-5H3/t16-,17+/m0/s1 KEGG:D09386 PDBeChem:469 PMID:20201574 PMID:21659629 PMID:22868770 PMID:23032694 PMID:23841999 PMID:25749612 Reaxys:11328447 SCIO 469 SCIO-469 SCIO469 Scios 469 ZMELOYOKMZBMRB-DLBZAZTESA-N chebi_ontology talmapimod