CD4-positive helper T cell A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions. CALOHA:TS-1146 CD4-positive T-helper cell CD4-positive helper T lymphocyte CD4-positive helper T-cell CD4-positive helper T-lymphocyte FMA:70572 cell CD4-positive, alpha-beta T cell helper T cell