endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0004175 GO:0016809 Reactome:REACT_10017 Reactome:REACT_101348 Reactome:REACT_101866 Reactome:REACT_101873 Reactome:REACT_102952 Reactome:REACT_103814 Reactome:REACT_104331 Reactome:REACT_104435 Reactome:REACT_104684 Reactome:REACT_104793 Reactome:REACT_105135 Reactome:REACT_105245 Reactome:REACT_105748 Reactome:REACT_106234 Reactome:REACT_106385 Reactome:REACT_106617 Reactome:REACT_106687 Reactome:REACT_107139 Reactome:REACT_107146 Reactome:REACT_108185 Reactome:REACT_108448 Reactome:REACT_108642 Reactome:REACT_109047 Reactome:REACT_109186 Reactome:REACT_109261 Reactome:REACT_110165 Reactome:REACT_110191 Reactome:REACT_110448 Reactome:REACT_110469 Reactome:REACT_110487 Reactome:REACT_110752 Reactome:REACT_111098 Reactome:REACT_111104 Reactome:REACT_111172 Reactome:REACT_112076 Reactome:REACT_113623 Reactome:REACT_113749 Reactome:REACT_114002 Reactome:REACT_114449 Reactome:REACT_114993 Reactome:REACT_115363 Reactome:REACT_115913 Reactome:REACT_1210 Reactome:REACT_13413 Reactome:REACT_13491 Reactome:REACT_13505 Reactome:REACT_1355 Reactome:REACT_13609 Reactome:REACT_1471 Reactome:REACT_15476 Reactome:REACT_1673 Reactome:REACT_20637 Reactome:REACT_2142 Reactome:REACT_25343 Reactome:REACT_28448 Reactome:REACT_28452 Reactome:REACT_28694 Reactome:REACT_29497 Reactome:REACT_29888 Reactome:REACT_30554 Reactome:REACT_31644 Reactome:REACT_32286 Reactome:REACT_32345 Reactome:REACT_32454 Reactome:REACT_33103 Reactome:REACT_33361 Reactome:REACT_33702 Reactome:REACT_34207 Reactome:REACT_34441 Reactome:REACT_38775 Reactome:REACT_480 Reactome:REACT_6715 Reactome:REACT_6777 Reactome:REACT_6826 Reactome:REACT_6878 Reactome:REACT_6937 Reactome:REACT_75798 Reactome:REACT_75871 Reactome:REACT_78097 Reactome:REACT_78726 Reactome:REACT_78745 Reactome:REACT_78867 Reactome:REACT_79225 Reactome:REACT_79268 Reactome:REACT_79271 Reactome:REACT_79593 Reactome:REACT_79599 Reactome:REACT_79815 Reactome:REACT_79882 Reactome:REACT_80109 Reactome:REACT_80331 Reactome:REACT_80442 Reactome:REACT_80463 Reactome:REACT_80748 Reactome:REACT_80774 Reactome:REACT_80978 Reactome:REACT_81238 Reactome:REACT_81327 Reactome:REACT_81867 Reactome:REACT_81958 Reactome:REACT_82043 Reactome:REACT_82474 Reactome:REACT_82600 Reactome:REACT_82845 Reactome:REACT_82963 Reactome:REACT_83099 Reactome:REACT_83216 Reactome:REACT_83748 Reactome:REACT_84139 Reactome:REACT_85078 Reactome:REACT_86353 Reactome:REACT_86565 Reactome:REACT_873 Reactome:REACT_88382 Reactome:REACT_88509 Reactome:REACT_88535 Reactome:REACT_88610 Reactome:REACT_88818 Reactome:REACT_88854 Reactome:REACT_89011 Reactome:REACT_89036 Reactome:REACT_89437 Reactome:REACT_89505 Reactome:REACT_89706 Reactome:REACT_90062 Reactome:REACT_9018 Reactome:REACT_9034 Reactome:REACT_9035 Reactome:REACT_90527 Reactome:REACT_90608 Reactome:REACT_91284 Reactome:REACT_91685 Reactome:REACT_91903 Reactome:REACT_92046 Reactome:REACT_92221 Reactome:REACT_92347 Reactome:REACT_92586 Reactome:REACT_92969 Reactome:REACT_93063 Reactome:REACT_93174 Reactome:REACT_93453 Reactome:REACT_93935 Reactome:REACT_94290 Reactome:REACT_9466 Reactome:REACT_94694 Reactome:REACT_95326 Reactome:REACT_95413 Reactome:REACT_95513 Reactome:REACT_95865 Reactome:REACT_96387 Reactome:REACT_96712 Reactome:REACT_96853 Reactome:REACT_96908 Reactome:REACT_97049 Reactome:REACT_97235 Reactome:REACT_97302 Reactome:REACT_97473 Reactome:REACT_97709 Reactome:REACT_97826 Reactome:REACT_97966 Reactome:REACT_98412 Reactome:REACT_98429 Reactome:REACT_98617 Reactome:REACT_98707 Reactome:REACT_98822 Reactome:REACT_98901 Reactome:REACT_98932 Reactome:REACT_99506 Reactome:REACT_99644 elastase activity endoprotease activity molecular_function proteasome endopeptidase activity proteinase