endopeptidase activity serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 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Reactome:REACT_104436 Reactome:REACT_104461 Reactome:REACT_104513 Reactome:REACT_104582 Reactome:REACT_104633 Reactome:REACT_104789 Reactome:REACT_104808 Reactome:REACT_104872 Reactome:REACT_104930 Reactome:REACT_105381 Reactome:REACT_105667 Reactome:REACT_105786 Reactome:REACT_106150 Reactome:REACT_106201 Reactome:REACT_106288 Reactome:REACT_106360 Reactome:REACT_106442 Reactome:REACT_1065 Reactome:REACT_106545 Reactome:REACT_106587 Reactome:REACT_106621 Reactome:REACT_106696 Reactome:REACT_106726 Reactome:REACT_106877 Reactome:REACT_106997 Reactome:REACT_107059 Reactome:REACT_1071 Reactome:REACT_107173 Reactome:REACT_107386 Reactome:REACT_107456 Reactome:REACT_107494 Reactome:REACT_107597 Reactome:REACT_107831 Reactome:REACT_107946 Reactome:REACT_108231 Reactome:REACT_108261 Reactome:REACT_108266 Reactome:REACT_108267 Reactome:REACT_108525 Reactome:REACT_108824 Reactome:REACT_108968 Reactome:REACT_109057 Reactome:REACT_109058 Reactome:REACT_109495 Reactome:REACT_109499 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Reactome:REACT_19170 Reactome:REACT_19296 Reactome:REACT_2004 Reactome:REACT_2028 Reactome:REACT_20669 Reactome:REACT_2073 Reactome:REACT_2114 Reactome:REACT_214 Reactome:REACT_2146 Reactome:REACT_217 Reactome:REACT_2226 Reactome:REACT_23836 Reactome:REACT_23854 Reactome:REACT_23859 Reactome:REACT_23880 Reactome:REACT_23888 Reactome:REACT_23895 Reactome:REACT_23907 Reactome:REACT_23940 Reactome:REACT_23981 Reactome:REACT_245 Reactome:REACT_28116 Reactome:REACT_28152 Reactome:REACT_28164 Reactome:REACT_28332 Reactome:REACT_28354 Reactome:REACT_28382 Reactome:REACT_28391 Reactome:REACT_28533 Reactome:REACT_28597 Reactome:REACT_28631 Reactome:REACT_28673 Reactome:REACT_28723 Reactome:REACT_28758 Reactome:REACT_28923 Reactome:REACT_29316 Reactome:REACT_29593 Reactome:REACT_29596 Reactome:REACT_29653 Reactome:REACT_29792 Reactome:REACT_29846 Reactome:REACT_29855 Reactome:REACT_29954 Reactome:REACT_30094 Reactome:REACT_30232 Reactome:REACT_30422 Reactome:REACT_30489 Reactome:REACT_30505 Reactome:REACT_31158 Reactome:REACT_31164 Reactome:REACT_31280 Reactome:REACT_31419 Reactome:REACT_31420 Reactome:REACT_31582 Reactome:REACT_31786 Reactome:REACT_31846 Reactome:REACT_32001 Reactome:REACT_32108 Reactome:REACT_32118 Reactome:REACT_32241 Reactome:REACT_32341 Reactome:REACT_32350 Reactome:REACT_32753 Reactome:REACT_32785 Reactome:REACT_32919 Reactome:REACT_32975 Reactome:REACT_32977 Reactome:REACT_33012 Reactome:REACT_33038 Reactome:REACT_33127 Reactome:REACT_33210 Reactome:REACT_33288 Reactome:REACT_33326 Reactome:REACT_33367 Reactome:REACT_33418 Reactome:REACT_33841 Reactome:REACT_33939 Reactome:REACT_33975 Reactome:REACT_34064 Reactome:REACT_34085 Reactome:REACT_34137 Reactome:REACT_34159 Reactome:REACT_34262 Reactome:REACT_34275 Reactome:REACT_34474 Reactome:REACT_34555 Reactome:REACT_34558 Reactome:REACT_374 Reactome:REACT_37926 Reactome:REACT_41363 Reactome:REACT_41656 Reactome:REACT_420 Reactome:REACT_493 Reactome:REACT_547 Reactome:REACT_598 Reactome:REACT_59890 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Reactome:REACT_7990 Reactome:REACT_79971 Reactome:REACT_8002 Reactome:REACT_80078 Reactome:REACT_80147 Reactome:REACT_8026 Reactome:REACT_80346 Reactome:REACT_80454 Reactome:REACT_80614 Reactome:REACT_80657 Reactome:REACT_80718 Reactome:REACT_80779 Reactome:REACT_80788 Reactome:REACT_80828 Reactome:REACT_80892 Reactome:REACT_80961 Reactome:REACT_81323 Reactome:REACT_81333 Reactome:REACT_81337 Reactome:REACT_81354 Reactome:REACT_81372 Reactome:REACT_81541 Reactome:REACT_81561 Reactome:REACT_81777 Reactome:REACT_81795 Reactome:REACT_81849 Reactome:REACT_82153 Reactome:REACT_82158 Reactome:REACT_82372 Reactome:REACT_82390 Reactome:REACT_82497 Reactome:REACT_82637 Reactome:REACT_82647 Reactome:REACT_82729 Reactome:REACT_82816 Reactome:REACT_82968 Reactome:REACT_83445 Reactome:REACT_83461 Reactome:REACT_83499 Reactome:REACT_83770 Reactome:REACT_83777 Reactome:REACT_84044 Reactome:REACT_84046 Reactome:REACT_84129 Reactome:REACT_84217 Reactome:REACT_84258 Reactome:REACT_84261 Reactome:REACT_84305 Reactome:REACT_84322 Reactome:REACT_84434 Reactome:REACT_84524 Reactome:REACT_84531 Reactome:REACT_84561 Reactome:REACT_84599 Reactome:REACT_84623 Reactome:REACT_84646 Reactome:REACT_84664 Reactome:REACT_84693 Reactome:REACT_84795 Reactome:REACT_84822 Reactome:REACT_85002 Reactome:REACT_85145 Reactome:REACT_85207 Reactome:REACT_85433 Reactome:REACT_85582 Reactome:REACT_85635 Reactome:REACT_85732 Reactome:REACT_85824 Reactome:REACT_85897 Reactome:REACT_85916 Reactome:REACT_86048 Reactome:REACT_86053 Reactome:REACT_86117 Reactome:REACT_86243 Reactome:REACT_86385 Reactome:REACT_86440 Reactome:REACT_86442 Reactome:REACT_86459 Reactome:REACT_86497 Reactome:REACT_86530 Reactome:REACT_86627 Reactome:REACT_86670 Reactome:REACT_86747 Reactome:REACT_86842 Reactome:REACT_86885 Reactome:REACT_86898 Reactome:REACT_86969 Reactome:REACT_87075 Reactome:REACT_87266 Reactome:REACT_87452 Reactome:REACT_87454 Reactome:REACT_87599 Reactome:REACT_87700 Reactome:REACT_87792 Reactome:REACT_87800 Reactome:REACT_87920 Reactome:REACT_88355 Reactome:REACT_88360 Reactome:REACT_88496 Reactome:REACT_88788 Reactome:REACT_88823 Reactome:REACT_88980 Reactome:REACT_89126 Reactome:REACT_89188 Reactome:REACT_89330 Reactome:REACT_89358 Reactome:REACT_89476 Reactome:REACT_89486 Reactome:REACT_89678 Reactome:REACT_89776 Reactome:REACT_89824 Reactome:REACT_89888 Reactome:REACT_89976 Reactome:REACT_9 Reactome:REACT_90020 Reactome:REACT_90057 Reactome:REACT_90119 Reactome:REACT_90443 Reactome:REACT_905 Reactome:REACT_90541 Reactome:REACT_90557 Reactome:REACT_90602 Reactome:REACT_90751 Reactome:REACT_90855 Reactome:REACT_90888 Reactome:REACT_90902 Reactome:REACT_90939 Reactome:REACT_91056 Reactome:REACT_91167 Reactome:REACT_91387 Reactome:REACT_91461 Reactome:REACT_91543 Reactome:REACT_91726 Reactome:REACT_91877 Reactome:REACT_92031 Reactome:REACT_92103 Reactome:REACT_92110 Reactome:REACT_92215 Reactome:REACT_92228 Reactome:REACT_92253 Reactome:REACT_92261 Reactome:REACT_92422 Reactome:REACT_92693 Reactome:REACT_92748 Reactome:REACT_92823 Reactome:REACT_92949 Reactome:REACT_93064 Reactome:REACT_93142 Reactome:REACT_93274 Reactome:REACT_93405 Reactome:REACT_93445 Reactome:REACT_93463 Reactome:REACT_93480 Reactome:REACT_93511 Reactome:REACT_93561 Reactome:REACT_93736 Reactome:REACT_94000 Reactome:REACT_94036 Reactome:REACT_94312 Reactome:REACT_94368 Reactome:REACT_94599 Reactome:REACT_94754 Reactome:REACT_94901 Reactome:REACT_94902 Reactome:REACT_94933 Reactome:REACT_94955 Reactome:REACT_94965 Reactome:REACT_95107 Reactome:REACT_95139 Reactome:REACT_95191 Reactome:REACT_95211 Reactome:REACT_95236 Reactome:REACT_95276 Reactome:REACT_95431 Reactome:REACT_95949 Reactome:REACT_95979 Reactome:REACT_96137 Reactome:REACT_96193 Reactome:REACT_96270 Reactome:REACT_96343 Reactome:REACT_96382 Reactome:REACT_96526 Reactome:REACT_97100 Reactome:REACT_97110 Reactome:REACT_97353 Reactome:REACT_97421 Reactome:REACT_97432 Reactome:REACT_97564 Reactome:REACT_97673 Reactome:REACT_97699 Reactome:REACT_97708 Reactome:REACT_97710 Reactome:REACT_97801 Reactome:REACT_97855 Reactome:REACT_98063 Reactome:REACT_98097 Reactome:REACT_98147 Reactome:REACT_98165 Reactome:REACT_98203 Reactome:REACT_98267 Reactome:REACT_98357 Reactome:REACT_98392 Reactome:REACT_98494 Reactome:REACT_98565 Reactome:REACT_98659 Reactome:REACT_98696 Reactome:REACT_98749 Reactome:REACT_98786 Reactome:REACT_98917 Reactome:REACT_99191 Reactome:REACT_99384 Reactome:REACT_99395 Reactome:REACT_99405 Reactome:REACT_99429 Reactome:REACT_99443 Reactome:REACT_99555 Reactome:REACT_99585 Reactome:REACT_99900 Reactome:REACT_99921 Reactome:REACT_99987 blood coagulation factor activity molecular_function serine elastase activity serine-type peptidase activity