glutamate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. EC:1.4.1.3 GO:0004353 L-glutamate:NAD(P)+ oxidoreductase (deaminating) MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN MetaCyc:GLUTAMATE-SYN2-PWY Note that this term has a MetaCyc pathway reference as the pathway only has a single step. Reactome:REACT_100655 Reactome:REACT_100656 Reactome:REACT_104090 Reactome:REACT_105114 Reactome:REACT_106901 Reactome:REACT_109912 Reactome:REACT_112437 Reactome:REACT_112733 Reactome:REACT_113249 Reactome:REACT_114470 Reactome:REACT_1896 Reactome:REACT_28386 Reactome:REACT_710 Reactome:REACT_78365 Reactome:REACT_82868 Reactome:REACT_83965 Reactome:REACT_90113 Reactome:REACT_93428 Reactome:REACT_94386 Reactome:REACT_95081 Reactome:REACT_95259 Reactome:REACT_96021 glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+) glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) glutamic dehydrogenase activity molecular_function