phosphatidylinositol phospholipase C activity 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). EC:3.1.4.11 GO:0004435 KEGG:R03435 MetaCyc:3.1.4.11-RXN PI-PLC activity RHEA:23915 Reactome:REACT_100549 Reactome:REACT_101538 Reactome:REACT_103918 Reactome:REACT_104013 Reactome:REACT_104384 Reactome:REACT_105056 Reactome:REACT_105753 Reactome:REACT_106433 Reactome:REACT_107694 Reactome:REACT_108661 Reactome:REACT_109774 Reactome:REACT_111977 Reactome:REACT_112016 Reactome:REACT_112120 Reactome:REACT_112432 Reactome:REACT_112586 Reactome:REACT_113026 Reactome:REACT_113134 Reactome:REACT_113176 Reactome:REACT_113179 Reactome:REACT_113201 Reactome:REACT_113580 Reactome:REACT_113618 Reactome:REACT_113733 Reactome:REACT_113827 Reactome:REACT_113870 Reactome:REACT_113925 Reactome:REACT_113959 Reactome:REACT_114034 Reactome:REACT_114083 Reactome:REACT_114101 Reactome:REACT_114237 Reactome:REACT_114264 Reactome:REACT_114329 Reactome:REACT_114608 Reactome:REACT_114663 Reactome:REACT_114783 Reactome:REACT_115119 Reactome:REACT_116048 Reactome:REACT_12078 Reactome:REACT_12585 Reactome:REACT_15353 Reactome:REACT_22318 Reactome:REACT_22417 Reactome:REACT_28616 Reactome:REACT_31243 Reactome:REACT_34289 Reactome:REACT_77907 Reactome:REACT_79438 Reactome:REACT_80615 Reactome:REACT_80913 Reactome:REACT_82046 Reactome:REACT_84690 Reactome:REACT_86163 Reactome:REACT_86182 Reactome:REACT_87086 Reactome:REACT_87142 Reactome:REACT_87357 Reactome:REACT_87628 Reactome:REACT_87970 Reactome:REACT_88756 Reactome:REACT_88910 Reactome:REACT_90807 Reactome:REACT_93506 Reactome:REACT_94845 Reactome:REACT_97327 Reactome:REACT_97840 Reactome:REACT_98877 Reactome:REACT_99371 molecular_function monophosphatidylinositol phosphodiesterase activity phosphatidylinositol-4,5-bisphosphate hydrolysis phosphoinositidase C activity phosphoinositide phospholipase C activity triphosphoinositide phosphodiesterase activity phospholipase C activity