malic enzyme activity malate dehydrogenase (decarboxylating) (NAD+) activity 'malic' enzyme (S)-malate:NAD+ oxidoreductase (decarboxylating) (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating) Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. EC:1.1.1.38 EC:1.1.1.39 For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'. GO:0004471 GO:0004472 GO:0016619 KEGG:R00214 MetaCyc:1.1.1.39-RXN MetaCyc:MALIC-NAD-RXN NAD-linked malic enzyme NAD-malic enzyme activity NAD-specific malic enzyme RHEA:12656 malate dehydrogenase (decarboxylating) activity malate dehydrogenase (oxaloacetate-decarboxylating) activity molecular_function