malic enzyme activity malate dehydrogenase (decarboxylating) (NADP+) activity 'malic' enzyme (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating) Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. EC:1.1.1.40 For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'. GO:0004473 KEGG:R00216 L-malate:NADP oxidoreductase activity MetaCyc:MALIC-NADP-RXN NADP-linked decarboxylating malic enzyme NADP-malic enzyme activity NADP-specific malate dehydrogenase activity NADP-specific malic enzyme RHEA:18256 malate dehydrogenase (NADP, decarboxylating) malate dehydrogenase (decarboxylating, NADP) molecular_function