catalytic activity methylmalonyl-CoA mutase activity (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity (R)-methylmalonyl-CoA CoA-carbonylmutase activity (S)-methylmalonyl-CoA mutase activity Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. EC:5.4.99.2 GO:0004494 KEGG:R00833 MetaCyc:METHYLMALONYL-COA-MUT-RXN RHEA:22891 Reactome:REACT_110753 Reactome:REACT_114493 Reactome:REACT_19 Reactome:REACT_28603 Reactome:REACT_30850 Reactome:REACT_32125 Reactome:REACT_33463 Reactome:REACT_35053 Reactome:REACT_86041 Reactome:REACT_86718 Reactome:REACT_87467 Reactome:REACT_95870 Reactome:REACT_97766 Reactome:REACT_98331 UM-BBD_reactionID:r0922 methylmalonyl coenzyme A carbonylmutase activity methylmalonyl coenzyme A mutase activity methylmalonyl-CoA CoA-carbonyl mutase activity molecular_function