phospholipase C activity Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. GO:0004629 GO:0042298 MetaCyc:PHOSPHOLIPASE-C-RXN Reactome:REACT_100688 Reactome:REACT_102616 Reactome:REACT_102640 Reactome:REACT_103548 Reactome:REACT_105325 Reactome:REACT_105673 Reactome:REACT_107508 Reactome:REACT_109008 Reactome:REACT_109501 Reactome:REACT_109627 Reactome:REACT_109971 Reactome:REACT_110061 Reactome:REACT_110223 Reactome:REACT_112092 Reactome:REACT_112217 Reactome:REACT_112221 Reactome:REACT_112517 Reactome:REACT_112637 Reactome:REACT_112759 Reactome:REACT_112950 Reactome:REACT_113114 Reactome:REACT_113364 Reactome:REACT_113464 Reactome:REACT_113587 Reactome:REACT_114558 Reactome:REACT_114743 Reactome:REACT_115019 Reactome:REACT_115219 Reactome:REACT_18383 Reactome:REACT_19319 Reactome:REACT_265 Reactome:REACT_28636 Reactome:REACT_30576 Reactome:REACT_34377 Reactome:REACT_77887 Reactome:REACT_78670 Reactome:REACT_80473 Reactome:REACT_80604 Reactome:REACT_83349 Reactome:REACT_83947 Reactome:REACT_87114 Reactome:REACT_89248 Reactome:REACT_90096 Reactome:REACT_92753 Reactome:REACT_93255 Reactome:REACT_93698 Reactome:REACT_94137 Reactome:REACT_94162 Reactome:REACT_95661 Reactome:REACT_95943 Reactome:REACT_960 Reactome:REACT_96475 Reactome:REACT_98409 Reactome:REACT_98758 lecithinase C activity lipophosphodiesterase C molecular_function phosphatidase C