proteolysis ATP-dependent proteolysis GO:0006508 Reactome:REACT_105459 Reactome:REACT_106013 Reactome:REACT_106377 Reactome:REACT_107219 Reactome:REACT_110326 Reactome:REACT_733 Reactome:REACT_84556 Reactome:REACT_92566 Reactome:REACT_95969 Reactome:REACT_98959 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. Wikipedia:Proteolysis biological_process peptidolysis