Disease_Has_Abnormal_Cell Disease_Has_Finding Disease_May_Have_Cytogenetic_Abnormality Disease_Excludes_Finding CTRP Terminology CTRP Disease Terminology Tubulocystic Renal Cell Carcinoma CTRP Tubulocystic renal cell carcinoma Tubulocystic Renal Cell Carcinoma TcRCC C126303 Tubulocystic Renal Cell Carcinoma Tubulocystic renal cell carcinoma CL504875 Neoplastic Process A rare, cytologically high grade carcinoma that arises from the renal parenchyma. It is characterized by the presence of prominently dilated cystic spaces in a bland, fibrotic stroma. The lining cells have large irregular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Necrosis and mitotic figures are not present. It rarely metastasizes. GDC Malignant Tubulocystic Renal Cell Carcinoma Dilated Cystic Spaces Present GDC Terminology GDC Value Terminology ICD-O-3 Morphology Term Diagnosis Question Non-Clear Cell Renal Cell Carcinoma Mitotic Activity Desmoplastic Stroma Formation Aggressive Clinical Course Fibrotic Stroma Formation Necrosis Gain of Chromosome 17 Loss of Chromosome 9 Loss of Chromosome Y Malignant Cell with Large Nucleus and Abundant Eosinophilic Cytoplasm