CIB1 Gene Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis EV C126877 An extremely rare skin disorder usually inherited in an autosomal recessive pattern and caused by mutation(s) in the TMC6 or TMC8 gene, encoding transmembrane channel-like protein 6 and transmembrane channel-like protein 8, respectively. It is characterized by chronic human papillomavirus infection. Patients develop papillomatous wart-like lesions and pigmented plaques on the skin. It predisposes to cutaneous carcinomas, especially in situ and invasive squamous cell carcinomas. Disease or Syndrome Cellosaurus Lewandowsky-Lutz Dysplasia Epidermodysplasia Verruciformis C0014522 Cellosaurus Disease Terminology TMC6 Gene TMC8 Gene RHOH Gene IL7 Gene Immunodeficiency Syndrome Cutaneous Precancerous Condition