Bicuspid Aortic Valve Cellosaurus Disease or Syndrome C128803 C3808338 Bicuspid Aortic Valve Bicuspid Aortic Valve Bicommissural Aortic Valve A genetically heterogenous congenital anomaly in which the aortic valve has two leaflets. It affects 1-2 percent of the population. It is a clinically heterogeneous condition, with a high incidence of aortic valve and ascending aortic complications requiring surgery. Cellosaurus Disease Terminology SMAD6 Gene NOTCH1 Gene ROBO4 Gene Aortic Valve Disorder Congenital Heart Disease